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Acute toxicity was studied on Ketoprofen, one of the non-steroidal antiinflammatory analgesics, using SPF rats. Ketoprofen was intrarectally administered in three forms such as pure powder (KP), KP suspension in CMC solution (KP-CMC) and a mixture of KP with powdered basic materials of capsule (KP-T10). The results obtained were as follows:1. LD50 values of terms of KP were 84 mg/kg in male rats and 122 mg/kg in female rats when KP-CMC was administered intrarectally, and 117 mg/kg in male and 92 mg/kg in female when KP-T10 was administered intrarectally., while peroral administration of KP-CMC showed LD50 values of 68 mg/kg in males and 78 mg/kg in females in terms of KP. 2. Major toxic signs of KP were ulceration on small intestines and peritonitis. Degeneration of hepathocytes and decrease in thymus lymphocytes were also observed. 3. Minimum lethal dose of KP-T10 was slightly higher than that of KP-CMC.
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
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K Hiyoshi, and
K Matsuura, and
J Tsuchiya, and
T Tanabe
November 1973,
Geburtshilfe und Frauenheilkunde,
K Shimpo, and
M Takeuchi, and
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K Matsuura, and
J Tsuchiya, and
T Tanabe
March 1982,
Rinsho byori. The Japanese journal of clinical pathology,
K Shimpo, and
M Takeuchi, and
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K Hiyoshi, and
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J Tsuchiya, and
T Tanabe
October 1978,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Shimpo, and
M Takeuchi, and
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M Takahashi, and
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J Tsuchiya, and
T Tanabe
November 1977,
Kokyu to junkan. Respiration & circulation,
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
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K Matsuura, and
J Tsuchiya, and
T Tanabe
April 1979,
Neurologia medico-chirurgica,
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
I Asai, and
K Hiyoshi, and
K Matsuura, and
J Tsuchiya, and
T Tanabe
July 1979,
Monatsschrift fur Kinderheilkunde,
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
I Asai, and
K Hiyoshi, and
K Matsuura, and
J Tsuchiya, and
T Tanabe
January 1980,
Przeglad lekarski,
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
I Asai, and
K Hiyoshi, and
K Matsuura, and
J Tsuchiya, and
T Tanabe
December 1981,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
I Asai, and
K Hiyoshi, and
K Matsuura, and
J Tsuchiya, and
T Tanabe
October 1980,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
K Shimpo, and
M Takeuchi, and
M Iwata, and
M Takahashi, and
I Asai, and
K Hiyoshi, and
K Matsuura, and
J Tsuchiya, and
T Tanabe
October 1978,
Nihon Jinzo Gakkai shi,
