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Hepatocytes isolated from 6-, 12-, 18-, and 30-month-old female Fischer F344 rats were examined by scanning electron microscopy. No significant change in cell size with age was observed. However, the surface morphology of the cells isolated from the older animals exhibited a significant increase in surface folds. This feature did not exceed 10% of the cell population until 12 months of age and continued to increase to 31% of the cells in 30-month-old rats. From 6 to 12 months of age, there was a significant increase in protein content of the hepatocytes. No further increase in protein content occurred during senescence. An increase in percentage of binuclear cells occurred after 24 months of age. Because ploidy and binucleation increase with increasing age, it appears that the nuclear/cytoplasmic ratio changes as a function of age.
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
November 1990,
Mechanisms of ageing and development,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
September 1981,
Mechanisms of ageing and development,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
December 1989,
Mechanisms of ageing and development,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
January 1986,
International journal of tissue reactions,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
October 1988,
Biochemical and biophysical research communications,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
July 2001,
The journals of gerontology. Series A, Biological sciences and medical sciences,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
September 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
October 1994,
Experimental cell research,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
January 1978,
Experimental gerontology,
G L Engelmann, and
A Richardson, and
A Katz, and
J A Fierer
January 1983,
Experimental gerontology,
