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The laser-Raman spectra of crystalline d(CpGpCpGpCpG) and of aqueous poly(dG-dC).poly(dG-dC) in high salt (4M NaCl) and low salt (0.1M NaCl) solutions have been measured and compared. The spectra of the crystal and the high-salt solution show a striking congruence, which indicates clearly that the high-salt form of the aqueous polymer has the left-handed Z-DNA structure of the crystalline oligomer. These two spectra differ substantially from that of the low-salt form of the polymer, which has been found previously to have spectral characteristics of the B-form of DNA. The high salt spectrum shows a unique line due to guanine residues at 625 cm-1 which should be useful for qualitative and possibly quantitative assessment of the amount of Z-structure present in a sample of DNA.
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
January 1984,
Magnesium,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
December 1984,
Journal of biomolecular structure & dynamics,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
January 1984,
Biochemistry,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
May 1985,
Biopolymers,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
August 1986,
Nucleic acids research,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
August 1985,
Nucleic acids research,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
August 1981,
Proceedings of the National Academy of Sciences of the United States of America,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
June 1985,
Nucleic acids research,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
December 1985,
Biochemistry,
T J Thamann, and
R C Lord, and
A H Wang, and
A Rich
October 1984,
Biopolymers,
