Evaluation of marketed and formulated furosemide tablets. 1981

N A Elgindy, and A A Ismail, and M A Gadalla

Five commercial brands of furosemide tablets were evaluated using the official and non-official tests of U.S.P. XIX. These tests include: uniformity of weight, hardness, friability and disintegration time. The results obtained showed that most of these brands failed to attain the U.S.P. requirements. The inclusion of different surface active agents in some of the new suggested formulae was proposed for improving the poor properties of such commercial furosemide tablets. In addition to the above quality control tests, dissolution rate studies of the new formulated tablets were carried out. The addition of 11.4% dioctyl sodium sulphosuccinate increased the dissolution rate up to 48.5% after 60 min. On the other hand, the same concentration of sodium lauryl sulphate caused complete tablet dissolution within 45 min. The effect of a higher concentration of sodium lauryl sulphate on the dissolution rate of furosemide has also been examined.

UI MeSH Term Description Entries
D008823 Micelles Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS. Micelle
D005665 Furosemide A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY. Frusemide,Fursemide,Errolon,Frusemid,Furanthril,Furantral,Furosemide Monohydrochloride,Furosemide Monosodium Salt,Fusid,Lasix
D006244 Hardness The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property. Hardnesses
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D013607 Tablets Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed) Tablet
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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