Biomaterial Database

Effects of glipizide on water and electrolyte handling in water-loaded humans. 1981

H G Preuss, and R Rodelas, and A Terlinsky, and M Gelfand

Renal handling of H2O, Na, and K during H2O diuresis was studied in the same healthy subjects on two occasions, after the administration of either 5 mg of the sulfonylurea, glipizide, or a placebo. Following glipizide, there was no significant overall change in creatinine clearance and the calculated rate of distal Na + K delivery (CH2O + C(Na + K)) in 9 individuals. However, the clearance of free water (CH2O) and the mean fraction of Na + K reabsorbed at the diluting site increased significantly from 8.5 +/- (SEM) 0.8 to 9.8 +/- (SEM) 0.8 ml/min/100 ml GFR (p less than 0.02) and from 55 +/- (SEM) 6 to 67 +/- (SEM) 7% (p less than 0.05), respectively. The mean rate of total Na and K excretion fell following glipizide (p less than 0.05). Our results, in conjunction with the results from similar type studies, suggest that ingestion of glipizide and other sulfonylureas that lack antidiuretic properties increase CH2O, at least in part, by augmenting ion reabsorption at the diluting sites of the nephron.

UI	MeSH Term	Description	Entries
D008657	Metabolic Clearance Rate	Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.	Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D009318	Natriuresis	Sodium excretion by URINATION.	Natriureses
D009399	Nephrons	The functional units of the kidney, consisting of the glomerulus and the attached tubule.	Nephron
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002712	Chlorides	Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.	Chloride,Chloride Ion Level,Ion Level, Chloride,Level, Chloride Ion
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D005913	Glipizide	An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.	Glidiazinamide,Glydiazinamide,Glypidizine,Glucotrol,Glupitel,K-4024,Melizide,Mindiab,Minidiab,Minodiab,Ozidia,K 4024,K4024
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults