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The dimensions of the small intestinal diffusion barrier interposed between luminal nutrients and their membrane receptors were determined from kinetic analysis of substrate hydrolysis by integral surface membrane enzymes. The calculated equivalent thickness of the unstirred water layer was too large to be compatible with the known dimensions of rat intestine. The discrepancy could be reconciled by consideration of the mucous coat overlying the intestinal surface membrane. Integral surface membrane proteins could not be labeled by an iodine-125 probe unless the surface coat was first removed. The mucoprotein surface coat appears to constitute an important diffusion barrier for nutrients seeking their digestive and transport sites on the outer intestinal membrane.
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
June 1984,
Canadian journal of physiology and pharmacology,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
April 1982,
Pflugers Archiv : European journal of physiology,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
April 1982,
The American journal of physiology,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
December 1992,
Journal of theoretical biology,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
December 1983,
Canadian journal of physiology and pharmacology,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
August 1974,
Biochimica et biophysica acta,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
January 1996,
JPEN. Journal of parenteral and enteral nutrition,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
January 2013,
Journal of theoretical biology,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
March 2010,
International journal of pharmaceutics,
K W Smithson, and
D B Millar, and
L R Jacobs, and
G M Gray
January 1993,
Journal of pediatric gastroenterology and nutrition,
