-transparent.png){kind=logo}
We assayed plasma activities of beta-galactosidase, beta-hexosaminidase, alpha-fucosidase and alpha-galactosidase involved in degradation of the glycoprotein molecule in 110 insulin-dependent diabetics aged 3-1/2 to 19 years and compared them to a group of normal youngsters. We correlated the plasma enzyme activities with the duration, control and sequelae of insulin-dependent diabetes. Insulin-dependent diabetics had a significantly higher plasma activity of beta-hexosaminidase and alpha-mannosidase (p less than 0.01) and a significantly lower plasma activity of alpha-fucosidase and alpha-galactosidase (p less than 0.01). Of the 5 enzymes studied, only plasma beta-hexosaminidase correlated with fasting and postprandial blood sugar (p less than 0.01), cholesterol and triglycerides (p less than 0.05). Additionally, poor control of diabetes was also associated with a significantly higher plasma beta-hexosaminidase activity (p less than 0.01). Proteinuria or an abnormal Addis count suggestive of renal involvement was associated with various changes in plasma acidic hydrolases. These changes may be related to insulin deficiency rather than hyperglycemia and may be genetically determined.
E Kohler, and
K J Sheth, and
T A Good
January 1979,
Diabetes care,
E Kohler, and
K J Sheth, and
T A Good
January 1981,
Diabetes care,
E Kohler, and
K J Sheth, and
T A Good
September 1985,
The American journal of physiology,
E Kohler, and
K J Sheth, and
T A Good
January 1986,
Archives of andrology,
E Kohler, and
K J Sheth, and
T A Good
August 1988,
Clinica chimica acta; international journal of clinical chemistry,
E Kohler, and
K J Sheth, and
T A Good
January 1995,
The Netherlands journal of medicine,
E Kohler, and
K J Sheth, and
T A Good
February 1990,
Pediatrics in review,
E Kohler, and
K J Sheth, and
T A Good
December 1991,
Current opinion in immunology,
E Kohler, and
K J Sheth, and
T A Good
April 1984,
Lancet (London, England),
