Biomaterial Database

Cimetidine clearance during intermittent and chronic peritoneal dialysis. 1981

M L Hyneck, and J F Murphy, and D E Lipschutz

A case report evaluating the clearance of cimetidine during intermittent peritoneal dialysis and chronic ambulatory peritoneal dialysis is presented. A 50-year-old white man with end-stage renal disease using chronic ambulatory peritoneal dialysis was hospitalized with uremic pericarditis. He was treated with indomethacin and aggressive intermittent peritoneal dialysis. Cimetidine 300 mg every 12 hours was prescribed for ulcer prophylaxis. After taking cimetidine for seven days, the clearance of cimetidine during intermittent peritoneal dialysis was evaluated by collecting blood and dialysate samples during a four-hour dialysis period. The patient was discharged using chronic ambulatory peritoneal dialysis. Cimetidine 300 mg every 12 hours was continued. One week after discharge, the clearance of cimetidine during a four-hour dwell period of chronic ambulatory peritoneal dialysis was measured. Cimetidine clearance was approximately 4 ml/min for both intermittent and chronic ambulatory peritoneal dialysis. Clinically unimportant quantities of cimetidine were removed by intermittent and chronic ambulatory peritoneal dialysis. The need for supplemental doses of cimetidine during peritoneal dialysis is not supported.

UI	MeSH Term	Description	Entries
D007676	Kidney Failure, Chronic	The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010530	Peritoneal Dialysis	Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.	Dialyses, Peritoneal,Dialysis, Peritoneal,Peritoneal Dialyses
D010531	Peritoneal Dialysis, Continuous Ambulatory	Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution.	CAPD,Continuous Ambulatory Peritoneal Dialysis
D002927	Cimetidine	A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.	Altramet,Biomet,Biomet400,Cimetidine HCl,Cimetidine Hydrochloride,Eureceptor,Histodil,N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine,SK&F-92334,SKF-92334,Tagamet,HCl, Cimetidine,Hydrochloride, Cimetidine,SK&F 92334,SK&F92334,SKF 92334,SKF92334
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D006146	Guanidines	A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man