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Sprague-Dawley rats were exposed to high (6--8 ppm) and moderate (1.5 ppm) amounts of ozone (O3) for various time periods. Response of the rat erythrocyte to ozone was monitored with red blood cell potassium (rubidium) influx studies, with storage stress combined with ultrastructural studies and with levels of erythrocyte glutathione peroxidase and superoxide dismutase. Erythrocytes of rats exposed to O3 showed no significant changes either in their potassium influx or in their glutathione peroxidase and superoxide dismutase activities compared to controls. Erythrocyte differential counts on O3-exposed animals showed significant changes initially as well as following storage stress compared to controls. Rats exposed to 8 ppm O3 for 4 h showed a marked increase in echinocytes. These consistent transformations from discocytes to echinocytes following O3 exposure suggest latent erythrocyte damage has occurred.
E C Larkin, and
S L Kimzey, and
K Siler
October 1992,
Research communications in chemical pathology and pharmacology,
E C Larkin, and
S L Kimzey, and
K Siler
November 1985,
Toxicology and industrial health,
E C Larkin, and
S L Kimzey, and
K Siler
April 1998,
Toxicology and applied pharmacology,
E C Larkin, and
S L Kimzey, and
K Siler
July 1990,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
E C Larkin, and
S L Kimzey, and
K Siler
May 1988,
The American journal of pathology,
E C Larkin, and
S L Kimzey, and
K Siler
January 1992,
Toxicology and applied pharmacology,
E C Larkin, and
S L Kimzey, and
K Siler
February 1987,
Environmental research,
E C Larkin, and
S L Kimzey, and
K Siler
October 1999,
Biulleten' eksperimental'noi biologii i meditsiny,
E C Larkin, and
S L Kimzey, and
K Siler
February 1988,
The American review of respiratory disease,
E C Larkin, and
S L Kimzey, and
K Siler
January 1982,
Journal of toxicology and environmental health,
