Biomaterial Database

Calorimetric investigations of saturated mixed-chain phosphatidylcholine bilayer dispersions. 1981

J T Mason, and C Huang, and R L Biltonen

A series of saturated mixed-chain phosphatidylcholines were prepared whose sn-2 acyl chains are two, four, six, and eight carbon atoms shorter than the sn-1 acyl chain. The calorimetric behavior of multilamellar bilayers of these phosphatidylcholines in excess water is investigated. The phosphatidylcholines display cooperative phase transitions which are dependent upon both the difference in chain length and the position of the acyl chains on the glycerol backbone of the phospholipid. A model is proposed which suggests that the thermotropic behavior of the mixed-chain phosphatidylcholines results from progressively greater interdigitation of the acyl chains of the phospholipid across the bilayer center, in the gel state, as the chain-length difference is increased beyond a minimum value. The disruptive effect of the terminal methyl groups of the fatty acyl chains upon the bilayer packing stability is also stressed. Dispersions of some of the mixed-chain phosphatidylcholines display transition endotherms which appear to be composites of two or more individual transition peaks. The dependence of this behavior on the thermal history of the dispersions is investigated. It is proposed that these peaks arise from the ability of the phosphatidylcholines' acyl chains to pack in more than one interdigitated conformation in the gel state.

UI	MeSH Term	Description	Entries
D008051	Lipid Bilayers	Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.	Bilayers, Lipid,Bilayer, Lipid,Lipid Bilayer
D008968	Molecular Conformation	The characteristic three-dimensional shape of a molecule.	Molecular Configuration,3D Molecular Structure,Configuration, Molecular,Molecular Structure, Three Dimensional,Three Dimensional Molecular Structure,3D Molecular Structures,Configurations, Molecular,Conformation, Molecular,Conformations, Molecular,Molecular Configurations,Molecular Conformations,Molecular Structure, 3D,Molecular Structures, 3D,Structure, 3D Molecular,Structures, 3D Molecular
D010713	Phosphatidylcholines	Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D002152	Calorimetry, Differential Scanning	Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.	Differential Thermal Analysis, Calorimetric,Calorimetric Differential Thermal Analysis,Differential Scanning Calorimetry,Scanning Calorimetry, Differential
D005227	Fatty Acids	Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)	Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D013816	Thermodynamics	A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)	Thermodynamic