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The diacetyl derivative of 4-hydroxyaminoquinoline 1-oxide (4-HAQO), the proximate carcinogen of 4-nitroquinoline 1-oxide, was reacted in vitro with purine nucleosides to give five adducts (three with guanosine and two with adenosine). The same nucleoside modifications were also obtained with a monoacetyl derivative of 4-HAQO which is probably 4-acetoxyaminoquinoline 1-oxide. The structure of the major adduct (the so-called dG III) was identified as N-(deoxyguanosin-C8-yl)-4-aminoquinoline 1-oxide. The isolation of this adduct from the 4-HAQO-modified DNA in vivo provides strong support for the hypothesis that the acetyl derivatives of 4-HAQO constitute a good model for the ultimate carcinogen.
B Bailleul, and
S Galiègue, and
M H Loucheux-Lefebvre
October 1980,
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B Bailleul, and
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B Bailleul, and
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M H Loucheux-Lefebvre
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B Bailleul, and
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M H Loucheux-Lefebvre
July 1969,
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B Bailleul, and
S Galiègue, and
M H Loucheux-Lefebvre
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B Bailleul, and
S Galiègue, and
M H Loucheux-Lefebvre
January 1972,
Biochemical and biophysical research communications,
B Bailleul, and
S Galiègue, and
M H Loucheux-Lefebvre
June 1974,
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B Bailleul, and
S Galiègue, and
M H Loucheux-Lefebvre
April 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
B Bailleul, and
S Galiègue, and
M H Loucheux-Lefebvre
January 1970,
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