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The bromodeoxyuridine differential chromatid labeling techniques were applied to the simultaneous in vivo examination of cell cycle kinetics and sister chromatid exchange (SCE) induction by various cancer chemotherapeutic agents in normal and Ehrlich ascites tumor cell populations. Compounds which yielded high ratios of SCE (in tumor cells):SCE (in normal cells) also produced greater inhibition of cellular replication in tumor cells when compared to normal cells. Thus, this approach permits in vivo assessment of induction of DNA damage by SCE analysis as well as inhibition of cellular replication by specific cancer chemotherapeutic agents in tumor and normal cell populations.
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
January 1982,
Anticancer research,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
March 1984,
Biological psychiatry,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
July 1982,
Cancer research,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
January 1987,
Bollettino della Societa italiana di biologia sperimentale,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
July 1974,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
April 2003,
Epilepsia,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
October 1998,
Indian journal of experimental biology,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
October 1976,
Experimental cell research,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
January 1980,
Advances in human genetics,
E L Schneider, and
Y Nakanishi, and
J Lewis, and
H Sternberg
May 1979,
Genetics,
