-transparent.png){kind=logo}
To evaluate the effect of maturation on the renal disposition of digoxin, the ratio of digoxin clearance to creatinine clearance was determined in 35 patients who were 3 days to 79 yr old. All were at steady-state levels for digoxin treatment. A mean ratio of 1.49 +/- 0.67 (SD) was obtained in the group of prepubertal children and infants greater than or equal to 2 mo of age. The mean ratio decreased to 0.82 +/- 0.25 (SD) in the adult group; adults were defined as sexually mature adolescents or older (P less than 0.005). The decrease in net renal tubular secretion of digoxin appears to occur at puberty. This observation can provide one explanation for the apparently larger doses of digoxin required by infants and children than by adults. It may also represent a developmental change in renal tubular physiology with broader significance than for digoxin disposition alone.
L A Linday, and
M A Engle, and
M M Reidenberg
January 1982,
European journal of clinical pharmacology,
L A Linday, and
M A Engle, and
M M Reidenberg
December 1997,
Therapeutic drug monitoring,
L A Linday, and
M A Engle, and
M M Reidenberg
July 1984,
Clinical pharmacology and therapeutics,
L A Linday, and
M A Engle, and
M M Reidenberg
January 1985,
Acta medica Scandinavica,
L A Linday, and
M A Engle, and
M M Reidenberg
October 1982,
Clinical physiology (Oxford, England),
L A Linday, and
M A Engle, and
M M Reidenberg
July 1988,
Journal of cardiovascular pharmacology,
L A Linday, and
M A Engle, and
M M Reidenberg
April 1975,
Clinical pharmacology and therapeutics,
L A Linday, and
M A Engle, and
M M Reidenberg
November 1981,
Research communications in chemical pathology and pharmacology,
L A Linday, and
M A Engle, and
M M Reidenberg
February 1977,
Research communications in chemical pathology and pharmacology,
L A Linday, and
M A Engle, and
M M Reidenberg
March 1981,
Pediatric research,
