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The effect of the beta 1-selective adrenoceptor blocker, metoprolol, on ventilatory function was studied in eight asthmatic patients in relation to the plasma level of the agent following its administration in ordinary and slow-release tablets. Metoprolol causes a slight decrease in ventilatory function as compared with placebo. The effect was most pronounced after administration of 200 mg in ordinary tablets, which induced the highest plasma levels. After administration of 200 mg in slow-release tablets the plasma levels were lower and the ventilatory effect was less marked. The bronchial obstruction largely improved after administration of the beta 2-receptor stimulating agent terbutaline. This study indicates, that when a larger dose of metoprolol is used in patients with obstructive lung disease, slow-release durules are to be preferred to ordinary tablets.
J H van den Bergh, and
C L van Herwaarden
January 1984,
Pharmatherapeutica,
J H van den Bergh, and
C L van Herwaarden
October 1979,
Annals of clinical research,
J H van den Bergh, and
C L van Herwaarden
January 1975,
Acta pharmacologica et toxicologica,
J H van den Bergh, and
C L van Herwaarden
July 1980,
International journal of clinical pharmacology, therapy, and toxicology,
J H van den Bergh, and
C L van Herwaarden
May 1974,
Acta pharmaceutica Suecica,
J H van den Bergh, and
C L van Herwaarden
January 1983,
European journal of clinical pharmacology,
J H van den Bergh, and
C L van Herwaarden
June 1992,
Arzneimittel-Forschung,
J H van den Bergh, and
C L van Herwaarden
January 1985,
Acta medica Scandinavica,
J H van den Bergh, and
C L van Herwaarden
May 1981,
Drug and therapeutics bulletin,
J H van den Bergh, and
C L van Herwaarden
October 1985,
British journal of clinical pharmacology,
