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In anesthetized dogs, intravenous administration of serotonin causes biphasic contraction of the urinary bladder followed by relaxation. The m-antagonist of serotonin, morphine inhibits the first phase of contraction but does not affect the second phase and relaxation. The T-antagonist tipindole exerts no effect on the serotonin-induced contraction and relaxation of the detrusor. The D-antagonists, LSD-25, dihydroergotamine, droperidol and cyproheptadine produce no effect on the first phase of contraction but inhibit the second one and successive relaxation of the urinary bladder detrusor. In addition to D-antagonists of serotonin, the relaxation of the detrusor is also suppressed by inderal and guanethidine which indicates the participation of the sympathetic component in the effect realization. The serotonin-induced relaxation of the detrusor is not suppressed by benzohexonium.
E L Vishnevskiĭ, and
I N Pidevich
February 1979,
The Urologic clinics of North America,
E L Vishnevskiĭ, and
I N Pidevich
March 2006,
BJU international,
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January 1959,
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October 1997,
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E L Vishnevskiĭ, and
I N Pidevich
January 1991,
Acta physiologica Hungarica,
E L Vishnevskiĭ, and
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January 1999,
Experimental physiology,
E L Vishnevskiĭ, and
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November 2003,
Urology,
E L Vishnevskiĭ, and
I N Pidevich
November 1959,
La Revue du praticien,
E L Vishnevskiĭ, and
I N Pidevich
January 1968,
Farmakologiia i toksikologiia,
