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In order to characterize the effector mechanism of "in vitro' lymphocytotoxicity against isolated rabbit liver cells in acute viral hepatitis (AVH), the test was performed in 4 patients with type A, in 8 with type, B, and in 2 patients with non-A non-B AVH: (a) using peripheral blood lymphocytes; (b) after enzymatic digestion of the surface membrane immunoglobulins of these lymphocytes, and (c) as in b with addition of patients' sera. 78.5% of the patients had an elevated cytotoxicity which did not change when the lymphocytes were treated as in b and c. Only the 2 patients which progressed to chronicity had an elevated cytotoxicity which disappeared after enzymatic exposure and reappeared with the addition of patients' sera. The results suggest that "in vitro' cytoxicity in recovering AVH is not antibody dependent, but probably of spontaneous type. On the contrary an antibody-dependent cytotoxicity is present in the 2 cases of AVH who progressed to chronicity.
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
January 1981,
Gastroenterologie clinique et biologique,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
January 1981,
Bollettino dell'Istituto sieroterapico milanese,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
July 1977,
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G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
February 1983,
Liver,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
January 1980,
Archivio per le scienze mediche,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
December 1982,
Gastroenterologie clinique et biologique,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
April 1982,
Minerva medica,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
August 1978,
Minerva medica,
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
May 1981,
Deutsche medizinische Wochenschrift (1946),
G F Stefanini, and
M Bernardi, and
F Miglio, and
E Mariani, and
F Chiodo, and
A Facchini, and
G Labò, and
G Gasbarrini
December 1988,
The Tohoku journal of experimental medicine,
