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20 mg metoclopramide, intramuscularly administered to 10 healthy males and 10 healthy females, induced a significant increase in serum thyroid-stimulating hormone values in female subjects only. This finding suggests that dopamine does not play a major role in the regulation of thyroid-stimulating hormone secretion and that estrogens can act in the modulation of dopamine effects at the hypothalamic and/or pituitary level.
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