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Semisynthetic cephalosporins. IV. Synthesis and structure activity relationships of parenterally active 7-[4-(substituted methyl)phenyl]-acetamido-3-cephem-4-carboxylic acids. 1981
A Nudelman, and
F Haviv, and
A Patchornick, and
E Karoly-Hafely, and
F Braun-Bucholts, and
B Kaier, and
J Itzchaki, and
S Sasson, and
R C Erickson
A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino-delta-3-cephems to afford a family of parenterally active cephalosporins. A compound designated 13I had the broadest spectrum of activity and the highest potency of the group against both Gram-positive and Gram-negative bacteria. The activity of 13I included high potency against penicillinase-producing staphylococci and activity against anaerobes, including Bacteroides fragilis.
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