-transparent.png){kind=logo}
Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of plasma dissolves very well in 50 or 100 ml of distilled water and contains around 500 IU per bottle. The specific activity per mg protein is 0.19 IU and the fibrinogen concentration is half that in frozen cryoprecipitate. This method of drying causes no appreciable loss in the factor VIIIC activity and little denaturation as shown by the factor-VIII-related antigen/factor VIIIC ratio of 1.7.
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
February 1986,
Thrombosis research,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
November 1983,
Journal of clinical pathology,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
May 1983,
Journal of clinical pathology,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
September 1988,
Journal of clinical pathology,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
March 1987,
Thrombosis research,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
April 1968,
The Quarterly journal of medicine,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
March 1968,
German medical monthly,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
March 1967,
Lancet (London, England),
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
January 1970,
British journal of haematology,
G Millgan, and
R Graham, and
S Hanratty, and
W Muir, and
R Mitchell
March 2011,
Journal of Zhejiang University. Science. B,
