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A specific and sensitive method is described for the separation and determination of metabolites of radioactively labelled noradrenaline in very small amounts of brain tissue. This method gives reproducible results, it allows the direct determination of all major metabolites of noradrenaline from the same extract, and is suitable for quantitating a large number of samples in relatively short time. This method was used to investigate how the half-life (turnover) and the metabolism of noradrenaline in rat brain may be influenced by anaesthesia with nembutal. It was found that both the half-life time as well as the metabolism of noradrenaline are reduced during nembutal anaesthesia; in addition, the release of metabolites of noradrenaline into the blood is delayed. When studying the metabolism of neurotransmitters, it has to be considered that nembutal-narcosis influences the metabolic pattern of noradrenaline as well as its temporal changes.
G Köster, and
H Breuer
January 1981,
Archivos de neurobiologia,
G Köster, and
H Breuer
November 1973,
Zeitschrift fur klinische Chemie und klinische Biochemie,
G Köster, and
H Breuer
January 1973,
Brain research,
G Köster, and
H Breuer
September 1981,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
G Köster, and
H Breuer
August 1980,
Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete,
G Köster, and
H Breuer
January 1978,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
G Köster, and
H Breuer
January 1981,
Acta histochemica,
G Köster, and
H Breuer
November 1978,
Masui. The Japanese journal of anesthesiology,
G Köster, and
H Breuer
February 1974,
Sbornik lekarsky,
G Köster, and
H Breuer
December 1980,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
