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In a study on the frequency of the HLA A, B, C and DR antigens seen in 100 controls and 31 patients with rheumatoid arthritis, the authors found a significant increase in the DR4 antigen in rheumatoid arthritis. (50% as against 25%; X2 = 8,5; 0,04 greater than Pc greater than 0,008; RR = 3,43). The other antigens on loci A, B. C and DR are not altered significantly. However the increase in DR4 which does not seem to be related to the severity of the rheumatoid arthritis, seems to be proportional to the level of rheumatoid factor. The authors review literature on HLA in rheumatoid arthritis and the figures for the antigenic frequency of HLA-DR4 are compared with their own results. The findings are of interest especially from a pathogenic point of view.
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
January 1994,
Acta Universitatis Carolinae. Medica,
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
January 1979,
Tissue antigens,
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
March 1979,
Lancet (London, England),
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
March 1979,
Lancet (London, England),
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
March 1979,
Lancet (London, England),
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
January 1977,
Archivum immunologiae et therapiae experimentalis,
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
January 1981,
Voprosy revmatizma,
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
August 1983,
Arthritis and rheumatism,
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
October 1994,
American journal of human genetics,
G Llorca, and
H Betuel, and
L Gebuhrer, and
M P Deslous-Paoli, and
E André-Fouet, and
B Bonvoisin, and
M Bouvier, and
E Lejeune
October 1987,
British journal of rheumatology,
