Biomaterial Database

The use of [99mTc](2,6-diethylacetanilide)-iminodiacetic acid ([99mTc]HIDA) in evaluating normal hepatobiliary dynamics. 1981

J Schoubye, and E Oester-Joergensen, and S A Pedersen

Scintigraphic examination with [99mTc]HIDA was used to investigate fasting hepatobiliary dynamics in thirty normal subjects, fifteen males and fifteen females. Ten were studied in duplicate. All subjects visualized the bile ducts and showed gallbladder filling within 60 min. All but three demonstrated excretion of bile to the duodenum. Only five subjects showed activity in the gut before gallbladder visualization. Twenty-one had one or more contractions of the gallbladder. A significant positive correlation was found between age and excretory liver function in males, signifying a lower excretory capability with advancing age. The median percentage deviation for gallbladder and gut visualization in repeat tests was 40% and 88%, respectively. It is concluded that the hepatic bile in the fasting state is delivered to the gallbladder as well as to the duodenum. Furthermore, the results suggest a cyclic function of the biliary tract based upon coordination between the gallbladder and the sphincter of Oddi.

UI	MeSH Term	Description	Entries
D007098	Imino Acids	Carboxylic acids that contain an imino group (C	Amino Acids, Secondary,Acids, Secondary Amino,Secondary Amino Acids,Acids, Imino
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D004386	Duodenum	The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.	Duodenums
D005215	Fasting	Abstaining from FOOD.	Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005260	Female		Females
D005704	Gallbladder	A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.	Gallbladders