Consolidation of platelet aggregates by fibrin despite heparin anticoagulation.
1981
L J Wurzinger, and
P Blasberg, and
H Schmid-Schönbein
UI
MeSH Term
Description
Entries
D010974
Platelet Aggregation
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Aggregation, Platelet
D005337
Fibrin
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
Antithrombin I
D006493
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.