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The in vivo equivalent of pA2 values were determined in rat tail-flick and mouse hot-plate tests for naloxone against morphine, beta-endorphin and a synthetic enkephalin analog, (D-Met2,Pro5)-enkephalinamide, as analgesics. In mice the apparent pA2 value of naloxone against morphine (6.86) was similar to that found by previously and essentially the same values were obtained against the opioid peptides, indicating homogenous receptor population for the analgesics studied. In rats the pA2 of naloxone against morphine (7.17) was lower than against either beta-endorphin (7.55) or (D-Met2,Pro5)-enkephalinamide (7.51), warning that in rats such a homogeneity of the "analgesic" receptor population as was observed for mice may not exist.
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
August 1978,
Pharmacology, biochemistry, and behavior,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
May 1980,
Neuropharmacology,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
January 1971,
Anesthesia and analgesia,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
January 1988,
Annals of the New York Academy of Sciences,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
January 1980,
Psychopharmacology,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
March 1982,
International journal of peptide and protein research,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
April 1977,
Life sciences,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
January 1982,
Peptides,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
January 1971,
Anesthesia and analgesia,
J I Székely, and
Z Dunai-Kovács, and
E Miglécz, and
A Z Rónai, and
S Bajusz
January 1975,
Pharmacology, biochemistry, and behavior,
