-transparent.png){kind=logo}
1. Administration of styrene (I) and styrene oxide (II) to rats resulted in the excretion of 2-hydroxymercapturic acids, N-acetyl-S-(1-phenyl-2-hydroxyethyl)cysteine (III) and N-acetyl-S-(2-phenyl-2-hydrosyethyl)cysteine (IV). Each appeared to be a mixture of diastereoisomers. 2. Administration of optically pure styrene oxide resulted in formation of one set of diastereoisomers. Racemic styrene oxide gave equal amounts of diastereoisomers. Thus the opening of the epoxide ring by glutathione S-transferases was stereospecific and the transferases showed no preference for one of the isomers of styrene oxide. 3. After administration of styrene the observed ratio of the diastereoisomers for both hydroxymercapturic acids was about 1:4. This leads to the conclusion that there is a stereoselective oxidation of styrene to styrene oxide, with a preference for the R-isomer.
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
August 1983,
Toxicology letters,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
August 1988,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
January 1996,
Archives of toxicology,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
May 1997,
American journal of industrial medicine,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
January 1982,
Environmental mutagenesis,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
June 1983,
Experientia,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
March 1982,
Experientia,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
May 1990,
Canadian journal of physiology and pharmacology,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
October 1981,
Journal of toxicology and environmental health,
L P Delbressine, and
P J Van Bladeren, and
F L Smeets, and
F Seutter-Berlage
August 1981,
Research communications in chemical pathology and pharmacology,
