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Hypoxanthine nucleotides synthesis in fresh and stored human erythrocytes. 1981

B Zachara, and J Klem, and M Kopff

Human erythrocytes incubated in inosine-pyruvate-phosphate (IPP) medium are able to accumulate great amounts of inosine monophosphate (IMP) and inosine triphosphate (ITP). Accumulation of ITP is low in freshly drawn cells. It increases during blood storage in acid-citrate-dextrose solution. Addition of labelled inosine or hypoxanthine to the IPP medium allowed to show the synthesis of small amounts of inosine diphosphate and the appearance of radioactivity in the ATP fraction. Conditions of incubation and the pathways of hypoxanthine nucleotides synthesis are discussed.

UI MeSH Term Description Entries
D007290 Inosine Diphosphate An inosine nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. IDP,Inosine Pyrophosphate,Riboxin,Riboxine,Diphosphate, Inosine,Pyrophosphate, Inosine
D007291 Inosine Monophosphate Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. IMP,Inosinic Acid,Ribosylhypoxanthine Monophosphate,Inosinic Acids,Sodium Inosinate,Acid, Inosinic,Acids, Inosinic,Inosinate, Sodium,Monophosphate, Inosine,Monophosphate, Ribosylhypoxanthine
D007292 Inosine Nucleotides Inosine Phosphates,Nucleotides, Inosine,Phosphates, Inosine
D007293 Inosine Triphosphate Inosine 5'-(tetrahydrogen triphosphate). An inosine nucleotide containing three phosphate groups esterified to the sugar moiety. Synonym: IRPPP. ITP,Triphosphate, Inosine
D007700 Kinetics The rate dynamics in chemical or physical systems.
D001793 Blood Preservation The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). Blood Preservations,Preservation, Blood,Preservations, Blood
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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