Biomaterial Database

Platelet MAO activity and personality characteristics. A study in schizophrenic patients and normal individuals. 1981

W F Gattaz, and H Beckmann

Low levels of platelet monoamine oxidase have been found in schizophrenic and bipolar depressive patients. The enzyme activity seems to correlate negatively with certain personality traits (social activity, sensation seeking, hypomania, positive affect and monotony avoidance) which are correlated to some extent with the score "extraversion" from the Eysenck Personality Questionnaire (EPQ). The present study was carried out in an attempt to investigate further the possible correlation between platelet MAO activity and the personality traits measured by the EPQ. 41 schizophrenic patients and 20 healthy probands were blindly examined for platelet MAO activity and personality characteristics. The enzyme activity was found to correlate negatively with the extraversion score in patients and healthy probands, which is in agreement with the data from other studies. This correlation is discussed and a hypothesis suggested.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008995	Monoamine Oxidase	An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.	Amine Oxidase (Flavin-Containing),MAO,MAO-A,MAO-B,Monoamine Oxidase A,Monoamine Oxidase B,Type A Monoamine Oxidase,Type B Monoamine Oxidase,Tyramine Oxidase,MAO A,MAO B,Oxidase, Monoamine,Oxidase, Tyramine
D010551	Personality	Behavior-response patterns that characterize the individual.	Personalities
D001792	Blood Platelets	Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.	Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D005120	Extraversion, Psychological	A state in which attention is largely directed outward from the self.	Extraversion (Psychology),Extraversion, Psychology,Extroversion, Psychological,Extroversion, Psychology,Extraversion,Extroversion,Extroversion (Psychology),Psychological Extraversion,Psychological Extroversion,Psychology Extraversion,Psychology Extraversions,Psychology Extroversion
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012559	Schizophrenia	A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder