-transparent.png){kind=logo}
In previous studies, we noted that treatment of pregnant rhesus monkeys with betamethasone resulted in a marked increase in fetal lung distensibility. The purpose of the present study was to determine whether these changes persisted during subsequent in utero development. Pregnant rhesus monkeys were treated with 2 mg of betamethasone intramuscularly from day 120 to day 133 and underwent delivery by cesarean section one month later. The treated fetuses were found to have smaller lungs (-31%; p less than 0.005), and lower alveolar stability (-14%; p less than 0.025) than the control fetuses. Additional findings included smaller weights for the brain (p less than 0.01), liver, pancreas, and heart (p less than 0.05). Smaller adrenal (p less than 0.025) and larger pituitary weights (p less than 0.05) and lower plasma corticoid concentrations (p less than 0.001) indicated long-standing adrenal insufficiency in the treated fetuses. These persistent sequelae caution the indiscriminate and prolonged use of these potent glucocorticoids during pregnancy.
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
August 2008,
Pediatric pulmonology,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
January 1980,
American journal of obstetrics and gynecology,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
January 1975,
Toxicology,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
September 1999,
Journal of neuropathology and experimental neurology,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
January 1991,
Biology of the neonate,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
October 2014,
Neuropharmacology,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
January 2000,
Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
April 2008,
Prescrire international,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
January 1989,
Akusherstvo i ginekologiia,
J W Johnson, and
W Mitzner, and
J C Beck, and
W T London, and
D L Sly, and
P A Lee, and
V A Khouzami, and
R L Cavalieri
February 2021,
Ultraschall in der Medizin (Stuttgart, Germany : 1980),
