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Human gastric juice samples were investigated from high- and low-risk areas (Colombia and Boston) for factors which influence the stability of nitrite and its potential for nitrosamine formation. The samples from individuals with chronic atrophic gastritis and intestinal metaplasia were not reactive to nitrite and supported a rate of nitrosation largely compatible with the nitrite and thiocyanate concentration. The samples from other individuals contained factors which destroyed nitrite and inhibited nitrosation. There were several samples from both groups which had an elevated rate of nitrosation catalyzed by unknown factors. It is suggested that continued hypochlorhydria might deplete gastric juice of its natural protective factors and lead to an elevated risk of gastric cancer in agreement with our earlier etiological model [1].
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
January 1989,
Voprosy onkologii,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
January 1986,
Voprosy onkologii,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
June 1978,
Lancet (London, England),
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
January 1980,
Carcinogenesis,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
May 1976,
Gut,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
November 1994,
Carcinogenesis,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
January 1976,
IARC scientific publications,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
January 1978,
Archives of oral biology,
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
May 1980,
Lancet (London, England),
S R Tannenbaum, and
D Moran, and
K R Falchuk, and
P Correa, and
C Cuello
January 1974,
Archiv fur Geschwulstforschung,
