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The thyroid status of twenty-seven African patients with gestational trophoblastic neoplasia (GTN) was studied. Fifteen patients were found to be biochemically hyperthyroid (eight patients with choriocarcinoma; seven with hydatidiform mole). Of these fifteen patients, nine were clinically thyrotoxic. The most serious complication of thyrotoxicosis was life-threatening acute pulmonary oedema with associated cardiac failure. It was found that when serum levels of the human chorionic gonadotrophin (hCG) reached a level of about 0.1 X 10(6) iu/1, thirteen of sixteen patients were biochemically hyperthyroid; at serum levels of 0.3 X 10(6) iu/1 of hCG most patients were clinically thyrotoxic. A feature of hyperthyroidism associated with GTN is that whereas T4 is invariably raised the T3:T4 ratio tends to be low (0.015 +/- 005); rT3:T3 ratios were high in this group. TSH levels were not increased.
R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
January 2013,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
August 1990,
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
November 2006,
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
January 1983,
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
January 1981,
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
June 2012,
Obstetrics and gynecology clinics of North America,
R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
February 1990,
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
March 1974,
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R J Norman, and
R W Green-Thompson, and
I Jialal, and
W P Soutter, and
N L Pillay, and
S M Joubert
January 2012,
The Journal of reproductive medicine,
