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1. The intracellular concentrations of Na+,K+ and Ca2+ were measured in the erythrocytes of spontaneously hypertensive rats and normotensive Wistar rats. 2. The intracellular Na+ concentration in hypertensive rats was slightly elevated at 3.16 +/- 0.25 compared with 2.85 +/- 0.35 mmol/l (P approximately 0.05) and intracellular Na+ activity was markedly increased in hypertensive rats. 3. Intracellular Ca2+ activity was 7519 +/- 28990 nmol/l of free water in hypertensive rats compared with 123 +/- 98 in controls (P less than 0.01). 4. The cytoplasm of hypertensive animals did not buffer Ca2+ as effectively as that of normal animals. 5. It is concluded that a decreased binding capacity of intracellular macromolecules for Na+ and Ca2+ may explain the disturbances of intracellular electrolyte composition in spontaneously hypertensive rats.
W Zidek, and
H Vetter, and
H Zumkley, and
H Losse
September 2000,
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W Zidek, and
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W Zidek, and
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W Zidek, and
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W Zidek, and
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