To give an antidepressant corresponds tro the wish of the prescriber and/or to the wish of the receiver. The prescribing therapeutist will try to modify the depressive situation of the patient with an active substance without side-effects and toxicity. On the contrary, the self-prescriber (narcotics, spirits, medicinal substances) will not take into consideration the notion of risk, either because he is looking for a quasi immediate modification of a dysphoric being or because the background of his wish is a modest extend the Order of Death. The wish of any prescriber has certain limits: - the possible future of the biochemical typology of depression;