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Repeated injections of des-tyrosine1-gamma-endorphin (DT gamma E) to rats subjectively increased sensitivity to handling. After 8 days of treatment, the animals were supersensitive to a low dose of morphine in the foot-shock test. Acute treatment with DT gamma E gave no significant increase in morphine sensitivity. The results indicate that DTgammaE given chronically interacts with opioid receptor-effector mechanisms.
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