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1. The molecular weight was 49,800 in SHRSP, quite different from the 43,300 of WK and the 49,500 and 37,700 of SHR, in females at the age of 200 days. 2. The molecular weight of plasma renin of female WK at the age of 90, 120, and 200 days ranged from 41,000 to 43,000 showing little variation. 3. The molecular weight of plasma renin varied according to the elevation of blood pressure. When blood pressure were 163, 200 to 250, and 267 mmHg, it showed 40,500, about 50,000, and about 60,000, respectively. 4. When subjected to an acid treatment, the high molecular type of SHRSP, showing molecular weights of plasma renin of about 50,000 to 60,000, increased in plasma renin activity by from 1.3 to 4.0 times.
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