An experiment was conducted to test the hypothesis that bull calves of a larger, faster growing breed of cattle exhibit greater secretory activity of anabolic pituitary hormones than bull calves of a smaller, slower growing breed. Calves of both breeds were raised under similar conditions and maintained on the same diet for approximately 4 weeks before the blood sampling period. Simmental bull calves had higher (P less than .01) average daily gains and a heavier (P less than .01) mean body weight than Hereford bull calves. Overall plasma growth hormone (GH) concentrations were higher (P less than .01) in Simmental bull calves than in Hereford bull calves. Mean baseline GH was also higher (P less than .05) in Simmentals. Overall and baseline concentrations of prolactin (PRL) were similar for both breeds. Mean amplitude of PRL secretory spikes was higher (P less than .05) for Simmental than for Hereford bull calves. There was no breed effect on any variable of thyrotropin secretion. These data suggest that representatives of a larger, faster growing breed of cattle (Simmental) exhibit greater secretory activity of GH and PRL than do representatives of a smaller, slower growing breed (Hereford).