BIOMAT Database Logo BIOMAT Database Logo

[Spectroscopic study of interactions between nucleic acid bases and amino acid esters in dimethylsulfoxide]. 1981

A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ

Interactions between nucleic acid bases (A, T, U. C) and some amino acid esters have been investigated by IR and UV spectroscopies in dimethylsulfoxide. The stability of associates of amino acid esters with the bases was established to form the following sequence: C greater than A much greater than U, T. The obtained data show that stability of complexes between the bases and amino acid esters decreases in the order: His greater than Met greater than Arg greater than Lys greater than Ser greater than or approximately Gly. The association is apparently realized through formation of two H-bonds, one of them involving the carbonyl group of amino acid, and another--its side chain.

UI MeSH Term Description Entries
D011687 Purines A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
D011743 Pyrimidines A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D004121 Dimethyl Sulfoxide A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. DMSO,Dimethyl Sulphoxide,Dimethylsulfoxide,Dimethylsulphinyl,Dimethylsulphoxide,Dimexide,Rheumabene,Rimso,Rimso 100,Rimso-50,Sclerosol,Sulfinylbis(methane),Rimso 50,Rimso50,Sulfoxide, Dimethyl,Sulphoxide, Dimethyl
D004952 Esters Compounds derived from organic or inorganic acids in which at least one hydroxyl group is replaced by an –O-alkyl or another organic group. They can be represented by the structure formula RCOOR’ and are usually formed by the reaction between an acid and an alcohol with elimination of water. Ester
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D013056 Spectrophotometry, Ultraviolet Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Ultraviolet Spectrophotometry
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Interactions between nucleic acid bases.
February 1972, Journal of theoretical biology,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Enantiomeric interactions between nucleic acid bases and amino acids on solid surfaces.
May 2003, Nature materials,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Stacking interactions between protonated nucleic acid bases and aromatic amino acids: spectroscopic and structural analyses of m3CMP-tryptophan derivative complex.
January 1989, Nucleic acids symposium series,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
A spectroscopic probe of stacking interactions between nucleic acid bases and tryptophan residues of proteins.
December 1979, Nucleic acids research,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Synthetic spectroscopic models. Intramolecular stacking interactions between indole and connected nucleic acid bases. Hypochromism and fluorescence.
July 1975, Journal of the American Chemical Society,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Prototropic interactions of pyrimidine nucleic acid bases with acridine: a spectroscopic investigation.
August 2012, The journal of physical chemistry. B,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Metal ion-mediated specific interactions between nucleic acid bases of polynucleotides and amino acid side chains of polypeptides.
June 1975, Nucleic acids research,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Spectroscopic analysis of drug-nucleic acid interactions.
February 1982, CRC critical reviews in biochemistry,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Dynamic properties of interaction between nucleic acid bases and models of amino acids.
January 1989, Biochemistry international,
A P Gul'tiaev, and S A Samoĭlenko, and N V Zheltovskiĭ
Heterodimeric molecules including nucleic acid bases and 9-aminoacridine. Spectroscopic studies, conformations, and interactions with DNA.
May 1988, Biochemistry,
Copied contents to your clipboard!