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Pilomatrixoma (benign calcifying epithelioma of Malherbe). 1981

R B O'Grady, and G Spoerl

A 24-year-old white man had a large subcutaneous discolored tumefaction of the right lower lid, successfully treated by two separate incision and drainage procedures. Microscopic appearance initially suggested basal cell epithelioma, but further studies provided a correct diagnosis of pilomatrixoma (calcifying epithelioma of Malherbe). This lesion probably represents aberrant primitive germ cells differentiating towards a hair matrix cell. Basaloid and squamoid (shadow) cells with or without focal calcifications in shadow cell areas are typical, and the clinical presentation is also highly suggestive of pilomatrixoma.

UI MeSH Term Description Entries
D008297 Male Males
D002280 Carcinoma, Basal Cell A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471) Carcinoma, Basal Cell, Pigmented,Epithelioma, Basal Cell,Rodent Ulcer,Ulcer, Rodent,Basal Cell Carcinoma,Basal Cell Carcinomas,Basal Cell Epithelioma,Basal Cell Epitheliomas,Carcinomas, Basal Cell,Epitheliomas, Basal Cell,Rodent Ulcers,Ulcers, Rodent
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005142 Eyelid Neoplasms Tumors of cancer of the EYELIDS. Eyelid Neoplasm,Neoplasm, Eyelid,Neoplasms, Eyelid
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012878 Skin Neoplasms Tumors or cancer of the SKIN. Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm

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