Biomaterial Database

Steatorrhea during aflatoxicosis in chickens. 1981

D J Osborne, and P B Hamilton

Graded levels of dietary aflatoxin (0, .625, 1.25, 2.5, 5 and 10 microgram/g) were tested for their effect on lipid excretion in feces of young broiler chickens. There was a highly significant (P less than .01) increase at 1.25 microgram/g and above including a threefold increase at 10 microgram/g, while growth rate was decreased only at levels of 2.5 microgram/g and above. Pancreatic lipase, the primary fat digestive enzyme, was decreased significantly (P less than .05) at all levels of aflatoxin and at 10 microgram/g was only 40% of the control value, Bile, which is required for lipid digestion and absorption, was decreased highly significantly (P less than .01) in concentration by all growth inhibition levels of aflatoxin. A slight but significant ( P less than .05) increase in bladder size at growth inhibitory levels of aflatoxin appeared adequate to compensate for decreased bile concentration. A pair feeding technique showed the effect of aflatoxin on fecal lipids and pancreatic lipase occurred in diets low (2%) or high (17%) in fat. The steatorrhea caused by aflatoxin apparently reflects a lipid malabsorption syndrome caused by an impaired ability to digest lipids.

UI	MeSH Term	Description	Entries
D008286	Malabsorption Syndromes	General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.	Malabsorption Syndrome,Syndrome, Malabsorption,Syndromes, Malabsorption
D011200	Poultry	Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.	Fowls, Domestic,Domestic Fowl,Domestic Fowls,Fowl, Domestic,Poultries
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002446	Celiac Disease	A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.	Gluten Enteropathy,Sprue, Celiac,Sprue, Nontropical,Celiac Sprue,Gluten-Sensitive Enteropathy,Sprue,Disease, Celiac,Enteropathies, Gluten,Enteropathies, Gluten-Sensitive,Enteropathy, Gluten,Enteropathy, Gluten-Sensitive,Gluten Enteropathies,Gluten Sensitive Enteropathy,Gluten-Sensitive Enteropathies,Nontropical Sprue
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D004063	Digestion	The process of breakdown of food for metabolism and use by the body.
D000348	Aflatoxins	Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.	Aflatoxin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000821	Animal Feed	Foodstuff used especially for domestic and laboratory animals, or livestock.	Fodder,Animal Feeds,Feed, Animal,Feeds, Animal,Fodders
D001228	Aspergillosis	Infections with fungi of the genus ASPERGILLUS.	Aspergillus Infection,Aspergilloses,Aspergillus Infections,Infection, Aspergillus,Infections, Aspergillus