Biomaterial Database

Protein synthesis in rheumatoid synovial tissue. 1981

J D Smiley, and W L Hoffman

1. Function of synoviocytes and other cells in the synovium A. Histologic Considerations 1. Electron microscopic studies 2. In vivo and in vitro phagocytosis studies 3. Fluorescent antibody staining B. Culture techniques 1. Problems posed by study of isolated cells 2. Long-term explant cultures 3. Advantages of short-term incubations of synovial fragments 4. Isolation of immunoglobulins C. Non-Immunoglobulin Products of the Synovium 1. Products of normal synovium 2. Alterations induced by rheumatoid arthritis II. The Local Immune response in Rheumatoid Synovitis A. Evidence for Active Immune Stimulation 1. Meditators of cellular immunity in synovial fluid 2. Effect of synovectomy 3. Type and amount of immunoglobulin produced B. Local Commitment of Antibody Response 1. Effect of exogenous immunization 2. Rheumatoid factors. 3. Pepsin agglutinators C. 1. Relative enrichment for IgG-3 subclass 2. Increase in lambda-light chain composition III. Pathogenetic Considerations in Rheumatoid Arthritis A. Comparison of Rheumatoid versus Experimental Immune Synovitis 1. Chronic synovitis as a local immune response. 2. Role of cartilage complexes in substaining chronic synovitis B. Significance of the Restriction in the Immunoglobulin Response in Rheumatoid Arthritis 1. Analogy with other disease states in man 2. Common antigen in RA?

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008565	Membrane Proteins	Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.	Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D013583	Synovial Membrane	The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.	Synovium,Membrana Synovialis Capsulae Articularis,Membrane, Synovial,Membranes, Synovial,Synovial Membranes
D013585	Synovitis	Inflammation of the SYNOVIAL MEMBRANE.	Plica Syndrome,Synovial Plica Syndrome,Synovial Hypertrophy,Synovial Thickening,Hypertrophies, Synovial,Hypertrophy, Synovial,Plica Syndrome, Synovial,Synovial Hypertrophies,Synovial Thickenings,Synovitides,Thickening, Synovial,Thickenings, Synovial