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The effect of high-dose fentanyl anaesthesia (75 micrograms kg-1) on the metabolic and endocrine responses to cardiac surgery was compared with results obtained in similar patients who had received incremental doses of papaveretum. High-dose fentanyl anaesthesia prevented the increases in blood glucose, plasma cortisol and plasma growth hormone concentrations found before cardiopulmonary bypass, but during cardiopulmonary bypass was only effective in decreasing the hyperglycaemia. The continued administration of fentanyl following operation failed to suppress the hormonal and metabolic changes so that the total urinary excretion during the first 5 days after surgery was similar in both groups of patients. High-dose fentanyl anaesthesia was associated with only transient metabolic benefits confined to the period during operation.
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
January 1984,
Anaesthesia,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
April 1987,
Masui. The Japanese journal of anesthesiology,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
August 1994,
British journal of anaesthesia,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
September 1981,
British journal of anaesthesia,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
December 1983,
Masui. The Japanese journal of anesthesiology,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
April 1985,
Acta anaesthesiologica Scandinavica,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
January 1978,
Acta anaesthesiologica Scandinavica,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
May 1990,
Anaesthesia,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
January 1985,
Acta anaesthesiologica Scandinavica,
E S Walsh, and
J L Paterson, and
J B O'Riordan, and
G M Hall
June 1980,
British journal of anaesthesia,
