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Lung disaturated phosphatidylcholine is thought to by synthesized, at least partially, by remodelling of unsaturated phosphatidylcholines. In view of the putative role of acyl-CoA : lysophosphatidylcholine acyltransferase (EC 2.3.1.23) and lysophosphatidylcholine : lysophosphatidylcholine transacylase in this remodelling process the activity of these enzymes in the lung of various mammals was investigated. The acyl-CoA-dependent acylation pathway was easily detected in the microsomal fractions of all animals investigated. By contrast, the enzyme catalyzing a transacylation between two molecules of lysophosphatidylcholine was only present in the 100 000 X g supernatants of rat, rabbit and mouse lung. It appeared to be undetectable in these fractions from guinea pig, bovine, pig, horse and sheep lung. These results provide and additional argument for the idea that the transacylation does not contribute to the synthesis of dipalmitoyl phosphatidylcholine in vivo.
G P Van Heusden, and
H Van den Bosch
May 1988,
Biochimica et biophysica acta,
G P Van Heusden, and
H Van den Bosch
January 2020,
Frontiers in plant science,
G P Van Heusden, and
H Van den Bosch
March 1982,
Biochimie,
G P Van Heusden, and
H Van den Bosch
February 2015,
Planta,
G P Van Heusden, and
H Van den Bosch
October 2021,
Molecular biotechnology,
G P Van Heusden, and
H Van den Bosch
June 2021,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
G P Van Heusden, and
H Van den Bosch
February 2001,
Nihon rinsho. Japanese journal of clinical medicine,
G P Van Heusden, and
H Van den Bosch
October 1982,
The Journal of biological chemistry,
G P Van Heusden, and
H Van den Bosch
October 1982,
Biochimica et biophysica acta,
G P Van Heusden, and
H Van den Bosch
December 1983,
Biochemical Society transactions,
