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The carcinogenicity of benzyl chloride (BYC), benzal chloride (BAC), benzotrichloride (BTC) and benzoyl chloride (BOC), which were suspected as causative agents of lung cancer and maxillary malignant lymphoma of workers employed in factories producing BOC, was examined by skin applications in female ICR mice. After rather high dose exposure, BTC exhibited leukemogenic and pulmonary tumorigenic activities as well as potent dermal carcinogenic activity. After administration of the chemicals at the dose of 2.3 microliter/animal, twice a week for 50 weeks, BTC induced 68% incidence of skin cancers and 58% incidence of pulmonary tumors (including 10% of lung carcinomas) within 399 days. Incidence of skin cancers was 58% for BAC, 15% for BYC and 10% for BOC within 560 days. Considering the extent of possible exposure of the workers to these chemicals in the working environment and the carcinogenic potency of the chemicals tested, it can be concluded that BTC was very probably responsible for causing the cancers seen int he workers employed in manufacturing BOC.
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
January 1965,
Federation proceedings. Translation supplement; selected translations from medical-related science,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
September 1964,
Gigiena truda i professional'nye zabolevaniia,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
November 1964,
Journal of chromatography,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
July 1991,
International journal of dermatology,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
September 1976,
Journal of toxicology and environmental health,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
January 1974,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
January 1982,
Mutation research,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
January 1990,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
February 1986,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
K Fukuda, and
H Matsushita, and
H Sakabe, and
K Takemoto
October 1985,
Toxicology,
