Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells. 1978

D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich

UI MeSH Term Description Entries
D008727 Methotrexate An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Amethopterin,Methotrexate Hydrate,Methotrexate Sodium,Methotrexate, (D)-Isomer,Methotrexate, (DL)-Isomer,Methotrexate, Dicesium Salt,Methotrexate, Disodium Salt,Methotrexate, Sodium Salt,Mexate,Dicesium Salt Methotrexate,Hydrate, Methotrexate,Sodium, Methotrexate
D011099 Polyglutamic Acid A peptide that is a homopolymer of glutamic acid. Polyglutamate
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
January 1983, Advances in experimental medicine and biology,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
December 1982, Annals of the New York Academy of Sciences,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
August 1982, The Journal of clinical investigation,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
January 1983, Advances in experimental medicine and biology,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
August 1985, The Journal of biological chemistry,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
June 1981, Biochemical pharmacology,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
February 1977, Cancer research,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
May 1980, Proceedings of the National Academy of Sciences of the United States of America,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
May 1984, Biochemical pharmacology,
D S Rosenblatt, and V M Whitehead, and N Vera, and A Pottier, and M Dupont, and M J Vuchich
August 1985, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!