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The effect of stannous chloride on bone metabolism was examined in weanling male rats given oral dose of 1.0 mg Sn/kg at 12-h intervals for 28 days. Tin administration produced progressive increase in tin content of the femoral diaphysis and epiphysis. Calcium content in the femoral epiphysis but not diaphysis was significantly decreased by tin administration for 28 days, while inorganic phosphorus contents in the femoral diaphysis and epiphysis were not changed significantly. Acid and alkaline phosphatase activities in the femoral diaphysis and epiphysis were markedly reduced by tin administration for 3 days, and significant decreases in the femoral epiphysis were also observed at 28 days. Meanwhile, ATPase and pyrophosphatase activities in the femoral diaphysis and epiphysis were not altered significantly by tin administration. From the present study, of mineral composition and its related enzyme activity, the decreases of acid and alkaline phosphatase activities in the femoral epiphysis were regarded as the biochemical manifestation of the toxic action of inorganic tin.
M Yamaguchi, and
K Sugii, and
S Okada
February 1980,
Nihon eiseigaku zasshi. Japanese journal of hygiene,
M Yamaguchi, and
K Sugii, and
S Okada
August 1977,
Nihon eiseigaku zasshi. Japanese journal of hygiene,
M Yamaguchi, and
K Sugii, and
S Okada
August 1976,
Nihon eiseigaku zasshi. Japanese journal of hygiene,
M Yamaguchi, and
K Sugii, and
S Okada
August 1980,
Toxicology letters,
M Yamaguchi, and
K Sugii, and
S Okada
February 1993,
Radiology,
M Yamaguchi, and
K Sugii, and
S Okada
July 1953,
Journal of the American Medical Association,
M Yamaguchi, and
K Sugii, and
S Okada
January 1974,
Pathologia Europaea,
M Yamaguchi, and
K Sugii, and
S Okada
April 1981,
Toxicology and applied pharmacology,
M Yamaguchi, and
K Sugii, and
S Okada
January 1990,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
M Yamaguchi, and
K Sugii, and
S Okada
March 1980,
Toxicology letters,
