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In determining the carcinogenicity of chemical tested in a National Cancer Institute (NCI) bioassay, the following criteria are considered: (1) the adequacy of the bioassay data, (2) the presence of significantly increased incidences of tumor, (3) the adequacy of the number of animals at risk of developing tumors, (4) the adequacy of the dose of chemical administered, (5) the etiology and pathogenesis of the lesions, and (6) other factors that may influence an evaluation, such as a shortened latency period for tumor formation in dosed animals or the stability of the chemical. A decision tree for evaluating these factors is presented. A summary of the results of 200 NCl carcinogen bioassays is also reported. These procedures are presented in the hope that they may serve as discussion points for future developments in the field.
K C Chu, and
C Cueto, and
J M Ward
December 1981,
Seminars in oncology,
K C Chu, and
C Cueto, and
J M Ward
January 1983,
American journal of industrial medicine,
K C Chu, and
C Cueto, and
J M Ward
June 1984,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
K C Chu, and
C Cueto, and
J M Ward
July 1989,
Environmental health perspectives,
K C Chu, and
C Cueto, and
J M Ward
August 2003,
Current opinion in molecular therapeutics,
K C Chu, and
C Cueto, and
J M Ward
May 1947,
Canadian Medical Association journal,
K C Chu, and
C Cueto, and
J M Ward
June 1951,
Journal of the American Medical Association,
K C Chu, and
C Cueto, and
J M Ward
April 1953,
Boletin cultural e informativo - Consejo General de Colegios Medicos de Espana,
K C Chu, and
C Cueto, and
J M Ward
December 1937,
American journal of public health and the nation's health,
K C Chu, and
C Cueto, and
J M Ward
April 1972,
Cancer,
