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The hypolipidemic properties of ethyl 6-chlorochroman-2-carboxylate (II), ethyl 6-phenylchroman-2-carboxylate (III) and ethyl 6-cyclohexylchroman-2-carboxylate (IV) were compared to clofibrate (I) in fasted normolipidemic rats. The chroman analog II, like its parent compound, clofibrate, reduced serum and alpha-lipoprotein cholesterol concentrations. Although analog III had no effect on serum cholesterol, it caused a slight elevation of alpha-lipoprotein cholesterol concentration. Serum free cholesterol was increased and LCAT activity was reduced in clofibrate-treated rats. The hypolipidemic agents had no consistent effect on liver lipid concentrations and liver microsomal HMG-CoA reductase activity. In addition, we have shown that drug efficacies varied directly with seasonal variations in serum lipid concentrations.
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
January 1978,
Zeitschrift fur Versuchstierkunde,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
July 1973,
Lipids,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
November 1984,
Biochimica et biophysica acta,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
July 1981,
Biochemical pharmacology,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
January 1974,
Journal of medicinal chemistry,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
September 1967,
Endocrinology,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
January 1980,
Acta clinica Belgica,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
December 1996,
General pharmacology,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
April 1979,
Environmental research,
M O'Brien, and
S T Patel, and
A Mukhopadhyay, and
H A Newman, and
D R Feller, and
S S Kokrady, and
D T Witiak, and
R R Lanese, and
J C Rice
April 1979,
Biochemical pharmacology,
