Biomaterial Database

Anticoccidial efficacy of salinomycin (AHR-3096C) and compatibility with roxarsone in floor-pen experiments with broilers. 1981

L R McDougald, and K Keshavarz, and M Rosenstein

Five experiments were conducted to test the anticoccidial efficacy of salinomycin (AHR-3096C, A. H. Robins) at 66 ppm and its compatibility with roxarsone (50 ppm) under floor pen conditions Monensin (100, 121 ppm), lasalocid (75, 125 ppm), and shuttle programs of salinomycin-monensin (66/100 ppm) or monensin-salinomycin (100/66 ppm) were included for comparison. Coccidiosis exposure was provided by using the infected seeder bird technique. Salinomycin reduced the lesion scores significantly and improved the body weight and feed conversion in all the trials as compared to unmedicated groups. All three ionophores effectively reduced the lesion scores. Birds treated with salinomycin-monensin shuttle programs had lesion scores, body weight, and feed conversion that were not significantly different from the salinomycin treated birds, suggesting that this shuttle program could be used satisfactorily for control of coccidiosis. Lesion scores, body weight, and feed conversion data of the 4th and 5th trials suggested that the anticoccidial activity of salinomycin and roxarsone are additive. There was evidence of compensatory growth after withdrawal of salinomycin and monensin but not with lasalocid.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011200	Poultry	Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.	Fowls, Domestic,Domestic Fowl,Domestic Fowls,Fowl, Domestic,Poultries
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D011714	Pyrans		Pyran
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D003048	Coccidiosis	Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA.	Besnoitiasis,Besnoitiosis,Besnoitiases,Besnoitioses,Coccidioses
D004344	Drug Incompatibility	The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)	Drug Incompatibilities,Incompatibilities, Drug,Incompatibility, Drug
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia