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Pyrolysis-gas chromatography and chemical ionization mass fragmentography were combined to develop a specific, simple and rapid method for simultaneously measuring endogenous and stable isotopic variants of acetylcholine and choline with a detection limit of approximately 10(-12) mol. The recovery and reproducibility of the method are excellent, and the method is suitable for measuring acetylcholine and choline in discrete regions of rat brain and to measure incorporation of choline into acetylcholine, both of which uses are demonstrated. This method affords easy analysis of 40 samples in a working day. The new technique used to extract compounds from tissues and the modified gas flow arrangement may be useful to measure other compounds as well.
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
July 1975,
Analytical biochemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
December 1974,
Journal of neurochemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
October 1973,
Analytical biochemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
July 1994,
Clinical chemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
December 1993,
Journal of chromatography. A,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
May 1974,
Analytical chemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
November 1968,
Analytical chemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
June 1992,
Biological mass spectrometry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
September 1972,
Analytical chemistry,
J K Khandelwal, and
P I Szilagyi, and
L A Barker, and
J P Green
January 1974,
Life sciences,
