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The response of arterial pressure to an infusion of saralasin was compared to the effect of surgical correction of renal vascular lesions (3 to 6 months after surgery) in eleven patients whose hypertension was associated with uni or bilateral stenosis of renal artery. Saralasin was infused after four days of dietary sodium restriction (10--40 mEq/day). An excellent correlation (r = 0.83, p less than 0.005) between the effects of saralasin and surgery was obtained. There was no correlation between the response to saralasin or to surgery and the ratio of renal vein renin activities. It is suggested that saralasin may be a good tool for predicting the effect of surgery in renovascular hypertension, when infused in moderately sodium depleted patients.
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A Thevenet
July 1977,
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A Mimran, and
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November 1978,
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A Mimran, and
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A Thevenet
January 1979,
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A Mimran, and
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January 1979,
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A Mimran, and
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A Thevenet
November 1976,
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A Mimran, and
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A Thevenet
January 1981,
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A Thevenet
March 1979,
Kidney international. Supplement,
A Mimran, and
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A Thevenet
March 1977,
Annals of internal medicine,
A Mimran, and
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A Thevenet
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