Biomaterial Database

Zinc Depletion following experimental fluorosis in mice. 1981

K C Kanwar, and M Singh

The effect of fluoride administration on zinc levels in liver, kidney and bone, and on protein content (microgram/mg tissue wt) in liver and kidney was investigated by subjecting albino mice for 16 weeks to different concentrations of fluoride (0 ppm - control; 10 ppm - group I; 25 ppm - group II; 50 ppm - group III; 100 ppm - group IV; and 200 ppm- group V) in drinking water. Zinc levels decreased significantly in liver and bone of groups III, IV and V; the decrease being 17%, 25% and 44% (P less than 0.005) in the case of liver, and 14% (p less than 0.01), 24% (p less than 0.005), and 39% (p less than 0.005) in the case of bone in groups III, IV and V respectively. Zinc depletion in the kidney of the fluoridated animals was only statistically significant (p less than 0.005) in groups IV and V. Similarly the protein content also decreased in liver and kidney (in liver significant at p less than 0.005, p less than 0.01, and p less than 0.005; in kidney significant at p less than 0.005, p less than 0.05 and p less than 0.005 in groups III, IV and V respectively). The experimental animals, especially in groups IV (100 ppm F) and V (250 ppm F), also exhibited retardation in growth.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D001842	Bone and Bones	A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.	Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D005458	Fluoride Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of FLUORIDE compounds.	Poisoning, Fluoride,Fluoride Poisonings,Poisonings, Fluoride
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus